体内研究：舒尼替尼苹果酸盐具有非常好的口服生物利用度，在许多临床前肿瘤模型中非常有效，并且在有效剂量下具有良好的耐受性[1]。舒尼替尼（80mg / kg /天）抑制无胸腺小鼠中已建立的SF763T和Colo205肿瘤异种移植物的生长。舒尼替尼（SU11248）治疗有效抑制已建立的肿瘤异种移植物的生长[2]。舒尼替尼苹果酸盐是VEGFR，PDGFR，FGFR的抑制剂，并且用于治疗晚期肾细胞癌和胃肠道间质瘤。舒尼替尼苹果酸盐治疗的大鼠显示出比未治疗大鼠低得多的肿瘤生长水平，并且它们的肿瘤具有更小的坏死区域和更低的血管密度
激酶实验：进行生化测定以确定舒尼替尼对不同蛋白激酶的活性。使用含有RTK的完整细胞质结构域的谷胱甘肽S-转移酶 - 融合蛋白测定SU11248对Flk-1，PDGFRβ和FGFR1的Ki值。直接测定SU11248抑制配体依赖性RTK磷酸化或细胞增殖和促有丝分裂反应的能力的细胞试验使用40 ng / mL VEGF165（Flk-1 / KDR），0.5μg/ mL碱性FGF刺激的血清饥饿细胞进行（FGFR），或50 ng / mL PDGF-AA（PDGFRα）或PDGF-BB（PDGFRβ）
中文简介：
深圳天缘医药科技有限公司，是一家致力于为全球医药行业提供全方位服务的高科技企业。自成立以来，我们始终坚持以科技创新为核心，以满足客户需求为导向，为全球医药企业提供从药物发现到生产过程的一体化解决方案。我们的业务范围覆盖了药物研发、生产、销售、技术支持等多个领域，为客户提供全方位的服务支持。
我们的研发团队拥有世界一流的科研实力，汇集了众多国内外的药物研发专家和技术骨干。在药物研发过程中，我们秉持创新、高效、安全的原则，采用先进的技术手段和设备，充分发挥团队的专业优势，为客户提供高质量的药物研发服务。在生物药物的研发和生产过程中，我们采用了一系列创新技术和方法，有效地简化了生产流程，提高了生产效率，降低了生产成本，为客户带来了显著的经济效益。
我们的质量管理体系已通过FDA（美国食品药品监督管理局）、EMA（欧洲药品管理局）和NMPA（国家药品监督管理局）的认证，充分体现了我们在质量管理方面的严谨态度和高标准要求。为了更好地服务客户，我们在深圳前海自贸区投资建设了一座多功能医药研发中心，提供从药物筛选、药物设计、药物合成、药物评价等全过程的一站式服务。
在治疗重大疾病领域，我们取得了一系列令人瞩目的成果。在抗病毒、肿瘤、代谢、心血管等领域，我们凭借强大的研发实力和丰富的行业经验，为全球医药企业研发了众多高效、安全的创新药物。尤其在替尼药物方面，我们拥有无与伦比的能力和专业知识，为全球医药企业提供了高质量的替尼药物研发服务。
作为一家国际化的医药科技企业，我们与全球3200多家合作伙伴建立了良好的合作关系，为客户提供了全球范围内的业务支持和服务。在商业化药物开发过程中，我们始终坚持“真正的一站式”理念，为客户提供从药物研发、生产、销售到技术支持等全方位的服务，帮助客户实现药物的快速上市和商业化。
展望未来，深圳天缘医药科技有限公司将继续坚持创新驱动、科技领先的发展战略，加大研发投入，不断提升技术水平和服务质量，为全球医药行业的发展做出更大的贡献。我们将与全球合作伙伴共同努力，为人类健康事业的发展贡献智慧和力量，为创造美好的未来而不懈努力。
英文简介：
Shenzhen Tianyuan Pharmaceutical Technology Co., Ltd. is a high-tech enterprise dedicated to providing a full range of services for the global pharmaceutical industry.
Since its inception, we have always adhered to scientific and technological innovation as the core, to meet customer needs as the orientation, to provide global pharmaceutical companies with integrated solutions from drug discovery to production process.
Our business scope covers drug research and development, production, sales, technical support and other areas, to provide customers with a full range of service support.
Our R & D team has world-class scientific research strength and brings together many top drug R & D experts and technical backbones at home and abroad.
In the process of drug research and development, we adhere to the principles of innovation, efficiency and safety, adopt advanced technical means and equipment, give full play to the professional advantages of the team, and provide customers with high-quality drug research and development services.
In the process of R & D and production of biopharmaceuticals, we have adopted a series of innovative technologies and methods to effectively simplify the production process, improve production efficiency, reduce production costs, and bring significant economic benefits to customers.
Our quality management system has been certified by FDA (US Food and Drug Administration), EMA (European Drug Administration) and NMPA (State Drug Administration), which fully reflects our stringent attitude and high standards in quality management.
In order to better serve our customers, we have invested in building a multi-functional pharmaceutical R & D center in Qianhai Free Trade Zone in Shenzhen, providing one-stop services for the whole process of drug screening, drug design, drug synthesis, drug evaluation and so on.
In the field of treating major diseases, we have made a series of remarkable achievements.
With our strong R & D strength and rich industry experience, we have developed many efficient and safe innovative drugs for global pharmaceutical companies in the fields of antiviral, oncology, metabolism, cardiovascular and so on.
Especially in the field of tini drugs, we have unparalleled ability and expertise to provide high-quality tini drug research and development services for global pharmaceutical companies.
As an international pharmaceutical technology enterprise, we have established a good cooperative relationship with more than 3200 partners around the world to provide customers with global business support and services.
In the process of commercial drug development, we always adhere to the "real one-stop" concept, providing customers with a full range of services from drug research and development, production, sales to technical support, to help customers achieve rapid drug marketing and commercialization.
Looking to the future, Shenzhen Tianyuan Pharmaceutical Technology Co., Ltd. will continue to adhere to the innovation-driven and technology-leading development strategy, increase R & D investment, constantly improve the technical level and service quality, and make greater contributions to the development of the global pharmaceutical industry.
We will make joint efforts with global partners to contribute wisdom and strength to the development of human health and make unremitting efforts to create a better future.
关键词：
英文：Filgotinib maleate,Pralsetinib (BLU-667),Pemigatinib,TIC10,Sodium phenylbutyrate,Mirogabalin besylate,Tyk2-IN-4(BMS986165),Ribociclib,Dotinurad,2,6-Bis(hydroxymethyl)-p-cresol,Brincidofovir,Finerenone,Peficitinib,Ticagrelor,Vonoprazan Fumarate (TAK-438),Sacubitril/valsartan (LCZ696),Upadacitinib,Tofacitinib (CP-690550) Citrate
中文：
非戈替尼、拉西替尼（BLU-667）、培米加替尼、onc201（TIC10）、4-苯基丁酸钠盐、米洛巴林、氘可来替尼（BMS-986165）、瑞博西尼（LEE011）、多替诺德、布罗福韦酯（CMX001）、2-羟基-5-甲基间苯二甲醇、非奈利酮、培菲替尼、替卡格雷、富马酸沃诺拉赞、沙卡布曲缬沙坦（LCZ696）、乌帕替尼、托法替尼
