Meropenem powder for injection
| Specification | 500mg / vial |
| Shelf life | 36 months |
| Storage | Store at or below 25°C. Do not freeze the reconstituted solution. |
Therapeutic indications
Meropenem for Injection is indicated for treatment of the following infections, in adults and children (aged 3 months and over), when the causative organisms are known or suspected to be resistant to commonly used antibiotics:
• Community acquired lower respiratory tract infection
• Hospital acquired lower respiratory tract infection
• Complicated urinary tract infection
• Febrile neutropenia
• Intra-abdominal and gynaecological (polymicrobial) infections
• Complicated skin and skin structure infections
• Meningitis
• Septicaemia .
Dose and method of administration
Dose
Adults
500 mg to 1 g by intravenous administration every 8 hours depending on type and severity of
infection, the known or expected susceptibility of the pathogen(s) and the condition of the
patient.
Exceptions
1. Febrile episodes in neutropenic patients - the dose should be 1 g every 8 hours.
2. Meningitis - the dose should be 2 g every 8 hours.
More information follow all directions given to you by your doctor and pharmacist carefully
Special populations
Adults with impaired renal function
Dosage should be reduced in adult patients with creatinine clearance less than 51 mL/min, as ascheduled below:
| Creatinine Clearance (mL/min) | Dose (based on unit doses of 500 mg, 1 g, 2 g every 8 hours) | Frequency |
| 26 to 50 | one unit dose | every 12 hours |
| 10 to 25 | one-half unit dose | every 12 hours |
| <10 | one-half unit dose | everyy 24 hours |
